Role of Integrins in Endothelial Mechanosensing of Shear Stress Dance Band on the Titanic: Biomechanical Signaling in Cardiac Hypertrophy Spatial Microstimuli in Endothelial Mechanosignaling Dynamic Regulation of Connexins in Connection With Mechanosignaling
نویسندگان
چکیده
Biomechanical signaling is a complex interaction of both intracellular and extracellular components. Both passive and active components are involved in the extracellular environment to signal through specific receptors to multiple signaling pathways. This review provides an overview of extracellular matrix, specific receptors, and signaling pathways for biomechanical stimulation in cardiac hypertrophy. (Circ Res. 2002;91:888-898.)
منابع مشابه
Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses.
Cells are constantly exposed to mechanical forces that play a role in modulating cellular structure and function. The cardiovascular system experiences physical forces in the form of shear stress and stretch associated with blood flow and contraction, respectively. These forces are sensed by endothelial cells and cardiomyocytes and lead to responses that control vascular and cardiac homeostasis...
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